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Combined use of physical methods and small sized carriers for percutaneous penetration enhancement with an aesthetic purpose.

Dermal and transdermal ingredients delivery (due to its non-invasiveness, avoidance of the first-pass metabolism, controlling the rate of ingredients input over a prolonged time, etc.) have gained significant acceptance. 

According to a recent publication in the journal of Advanced Drug Delivery Reviews ,Several methods are employed to overcome the permeability barrier of the skin, improving substance penetration into/through skin. Among chemical penetration enhancement methods, small sized carriers have been extensively studied. When applied alone, small sized carriers mostly deliver the ingredients to skin and can be used to alleviate many skin conditions.

To achieve effective transdermal delivery, micro carriers should be applied with physical methods, as they act synergistically in enhancing drug penetration. SQOOOM has made years of success in combined use of frequently used micro carriers (Hyaluronic acid, novel humectants, herbal based and natural organic ingredients of SQOOM serums) with the most efficient physical methods (An effective combination of iontophoresis and ultrasound without use of needles or injections) and demonstrates superiority of the combined use of nano carriers and physical methods in substance penetration enhancement compared to many non-scientific products in the market.

Reference article on PubMed published on March 2018.